The Evidence Base for 2025-26 Respiratory Season Immunizations
From Data to Decisions: The Evidence Base for 2025-26 Respiratory Season Immunizations
As we prepare for the upcoming respiratory virus season, it is important to recognize that flu, COVID, and RSV will all play significant roles in the months ahead. Following a flu season with nearly 270 pediatric deaths, clear and trustworthy information is essential to guide immunization decisions. Vaccines remain one of our most effective tools for preventing severe illness and death, but that protection depends on people knowing when and why to get vaccinated and trusting the guidance that informs those choices.
The Vaccine Integrity Project assembled a team of experts in epidemiology, infectious diseases, and evidence review to look at the recently published body of publicly available data concerning vaccine safety and efficacy for flu, COVID, and RSV immunizations. During the live stream on August 19th, the scientific research team focused on the effectiveness and safety of COVID-19 and RSV immunizations in pregnant, pediatric, and immunocompromised populations, coupled with a panel-led Q&A session.
Medical Society Guidelines
Individual medical societies create clinical guidelines and evidence-based recommendations to inform their providers and the public. The following guidelines have been published by US medical societies that are updated to the 2025-2026 Fall/Winter respiratory virus season:
